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The fasted state is criticalinsulin suppresses NNMT activity, so dosing during fed states reduces 5-Amino-1MQ's efficacy

doi: 10.1038/414782a

However, markedly elevated levels without supplementation may warrant GP review to exclude underlying conditions such as haematological disorders, liver disease, or renal impairment

These points show why its vital to talk to oncologists before taking any supplements

This is especially important for those who may have difficulty absorbing nutrients due to digestive issues, certain medical conditions, or simply because of age-related changes
