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doi: 10.1093/ajcn/34.9.1906

Among euthyroid individualsthose with biochemically normal thyroid functionthe KD is generally well tolerated, but subtle hormonal shifts may occur, particularly in those with underlying vulnerabilities or borderline thyroid reserve

Bypass pathway: when leukemia cells are deprived of Gln, the serine pathway upregulates the key serine enzymes phosphoglycerate dehydrogenase (PHGDH) and phosphoribosyltransferase (PSAT), leading to an increased demand for serine and exacerbation of serine dependence in leukemia cells [117]

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