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Notably, these pathological alternations and reductive stress were significantly normalized by replacing the wild-type G6PD with a hypomorphic G6PD mutant in the R120G mice (77), suggesting that the G6PD-mediated reductive stress contributes to the development of this disease

Oral doses can start at 300mg per day and go up depending on individual requirement

However, this may lead to an increased incidence of adverse reactions and may also lead to off-target or toxic reactions, decreasing patient compliance, which is an issue that needs to be addressed

Vasconcelos AR, Dos Santos NB, Scavone C, Munhoz CD (2019) Nrf2/ARE pathway modulation by dietary energy regulation in neurological disorders