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This review provides a comprehensive analysis of the anatomical considerations in drug absorption, formulation strategies, and technological advancements in intranasal drug delivery devices, emphasising its potential in overcoming traditional drug delivery barriers and unlocking new therapeutic potential for CNS and systemic applications

doi: 10.1023/A:1006841228483 28 Friedmann AngeliJPSchneiderMPronethBTyurinaYYTyurinVAHammondVJet al

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3 All microspecies with their charge values generated from the initial compound Partition and distribution coefficients Partition and distribution coefficients then can be expressed as follows: Partition coefficient of the neutral species is Partition coefficients of the anionic and the cationic species are and Distribution coefficient of the original molecule is The micro partition coefficient is the ratio of the concentration of two microspecies defined with p i as expressed with the next relation: Relation between macro and micro partition coefficients Macro partition coefficients * P 0 P i * can also be expressed as a function of micro partition coefficients p 0 p i

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