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Safety Monitoring Recommendations Based on the available clinical trial data, clinicians prescribing orforglipron should: (1) counsel patients about expected GI side effects during dose escalation, (2) follow the recommended dose-titration schedule to minimize GI intolerance, (3) monitor for signs of pancreatitis and discontinue if suspected, (4) assess hepatic and renal function at baseline and periodically, (5) screen for personal or family history of MTC or MEN 2, and (6) review concomitant medications for potential CYP3A-mediated drug interactions

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Improving Lipid Profiles: Some research suggests it may help improve cholesterol and triglyceride levels

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Oral supplementation almost never produces symptoms because the body absorbs only a small fraction of high-dose oral B12 and excretes the rest

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Store B12 Vial, and supplies in a cool dark place such as a cabinet Step 8

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Limits: 2002-present

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