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Dosing Recommendations for Combination Therapy Tirzepatide: Initiate at 2.5mg subcutaneously weekly, titrating by 2.5mg every 4 weeks to maintenance dose of 5-15mg weekly based on tolerance and efficacy

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doi: 10.1074/jbc.M109.054056, 54

This effect may be attributed to a marked reduction in the expression of MuRF1 and atrogin-1, thereby delaying age-dependent dysregulation of muscle mass through the modulation of genes involved in muscle regeneration and catabolism (66)