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Since the main cause is placental dysfunction, it has been associated with elevated OS
A study from The Netherlands (Riphagen, 2020) found that after 8.5 years of follow-up of an older cohort (median baseline age=65), a doubling of baseline MMA levels was associated with an increased risk of mortality (HR 11.48, CI 3.3239.64)
The IFcobalamin complex enters the enterocytes by pinocytosis after binding to specific receptors known as cubam receptors
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