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Elevated plasma concentrations of TMAO have also been linked with a long-term mortality risk in patients suffering from heart failure, advanced left-ventricular diastolic dysfunction, and atherosclerotic development in patients suffering from atherosclerotic coronary artery disease (Tang et al., 2013

Therefore, the authors suggested that TMNO is a useful biomarker of ASD [61]

Liao Y, Hu R, Wang Z, Peng Q, Dong X, Zhang X, et al

VPA is available as oral immediate-release, enteric-coated and delayed-release preparations, and as an intravenous formulation

The interplay among these modifications determines its transcriptional activity under metabolic stress
