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It was recently postulated that the gut microbiota may influence CIPN through macrophages [110], and after chemotherapy, the number of CD11b + CD45 hi cells, which are presumably macrophages, is significantly lower in the dorsal root ganglia of mice that receive water containing antibiotics than those receiving water alone [136]

Conclusion In conclusion, this systematic review demonstrates that the APOE4 genotype in mice is associated with compromised blood-brain barrier integrity, reflected by consistent pathogenic alterations in vascular morphology, cerebral blood flow dynamics, and mechanistic pathways linking ECM remodelling, junctional instability and metabolic dysregulation

High doses of caffeine can lead to jitteriness, increased heart rate, and anxiety

Vasc Health Risk Manag 7(1):169176