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Moreover, excessive APAP increases hepatic CXCL16 levels, CXCL16 deficiency significantly reduces the production of pro-inflammatory cytokines TNF- and IL-6, and inhibits neutrophils migration to the site of injury, other chemokines CXCL1 and CXCL2 expression are also diminished, suggesting that CXCL16 may be involved in neutrophil infiltration in APAP hepatotoxicity [38]

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10.3390/antiox11081511 180 ParhizkarS.HoltzmanD

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Gonzlez-Estecha M., Trasobares E.M., Tajima K., Cano S., Fernndez C., Lpez J.L., Unzeta B., Arroyo M., Fuentenebro F

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