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Furthermore, bromelain offers a unique mechanism for localized pain relief

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36 However, when MRP2 function is impaired [e.g., in Dubin-Johnson syndrome], MRP3 levels increase to provide a compensatory pathway for hepatic efflux

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Simultaneous activation of mu and delta opioid receptors reduces allodynia and astrocytic Connexin 43 in an animal model of neuropathic pain