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The trial also confirmed that the combination was well-tolerated, with gastrointestinal side effects being the most common adverse events

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Molecular evidence was established by quantifying the expression levels of Ki-67, CD98hc, caspase-3, and MMP-9 in fibroblasts treated with AEDG [53]

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Dysfunction within the CNS Brain imaging studies have demonstrated an association between PDPN and structural changes in key somatosensory regions, such as the thalamus and somatosensory cortex, and altered functional connectivity within ascending pain pathways and cortical regions involved in pain processing

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