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The TCA cycle dynamics seemed to be time-dependent, with an apparent activation at 48 h preferentially supported by anaplerotic aromatic amino acids, leucine and lysine

doi: 10.1089/ars.2008.2425

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Surprisingly, optimization using a combination of diet (lower blood glucose and higher blood -hydroxybutyrate), exercise (higher blood lactate), and NAD-related supplementation and modulation of the cytosol-mitochondria NAD-associated reducing equivalents shuttle (hereafter referred to as DEN therapy) increased ATP levels in both neurons and astrocytes toward values of the young metabolic systemcomparable to that of the top-scoring targeted therapy ( Figure 9A

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