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The BBBs vascular endothelial cells are very closely connected, around 50100 times closer than that of the peripheral micro-vessel endothelial cells resulting in tight intercellular junctions between cerebrovascular endothelial cells [3]

fruit rind, has been shown to possess significant antioxidant activity in vitro and recently been recognized for its therapeutic potential in metabolic syndrome

It plays an important role in cell division and regeneration, making it essential for proper skin cell turnover

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For these uses, you want the compound to stay in the gut which is exactly what oral delivery achieves