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ASCL2+ tumor cells modulate the response of colorectal cancer to MAPK targeting therapy

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Gastroenterology 123(2):461467 Ethics declarations Disclosures Jenifer Barri, Fady Yanni, Mohamed Sherif, Asha K

Early clinical trials indicated minimal activity, primarily because the drug couldnt penetrate the blood-brain barrier (BBB) effectively and because the tumor growth wasnt largely dependent on the targeted pathway ( Lapatinib, a dual inhibitor of EGFR and human epidermal growth factor receptor 2 (HER2), is the most frequently tested EGFR inhibitor in GB trials

In this overview, we'll explore the different types of B12, focusing on cyanocobalamin, to determine if it's harmful and under what circumstances it might pose risks to your health