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23 Despite advances in supportive care, ARDS remains a significant cause of morbidity and mortality in critically ill patients, with high mortality rates of 35% (for mild cases), 40% (for moderate cases), and 45% (for severe cases)

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However, restoration of mTOR, p70S6K, or 4E-BP1 was remarkably potent in protecting against neuronal apoptosis caused by these PD mimetics 10,15