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179 Response to External Stimuli In addition to designing nanomedicines that respond to endogenous physiological stimuli based on tumor characteristics such as low pH, low oxygen, high GSH, high ROS, and abnormal enzyme expression, nanomedicine delivery systems that respond to exogenous stimuli can also be designed (Figure 4), such as nanomedicines responsive to light, magnetic fields, ultrasound, and temperature

DOI: 10.1016/S1389-9457(03)00010-8 [DOI] [PubMed] [Google Scholar] 30.Sun S, Liu C, Jia Y, Wu J, Li H, Li X, et al

& Esser-von Bieren, J

Recent advances in neuroimaging technology allowing for in vivo quantification of GSH levels in the brain have shown decreased GSH in patients with MS compared to healthy controls, with the degree of depletion correlating with disease severity and showing parallel longitudinal decline over time (Mandal et al., 2015)