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Fundamental Concepts in Periodontal Regeneration It is important to underline the success of periodontal regeneration depends on several factors such as biofilm level, residual bleeding on probing, systemic conditions, smoking status, defect morphology, tooth mobility, early and late wound stability, type of biomaterials, choice of flap design and surgical skills of the clinician [23,24,25,26,27,28,29]
