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Plasmid isolation and purification were done using a plasmid miniprep kit (Qiagen, Germany) as per standard instructions

Although low pH may enhance apoptotic cell clearance via DEC205 78 , lactate predominantly drives a suppressive state by inhibiting IL-12 and CD80 expression via mechanisms involving early growth response 1 and serum response factor

In particular, studies showed that hexarelin treatment in animal murine models reduced brain damage by 39%

Additionally, MHC-II is present in LECs within tumors and lymph nodes (43, 226228), as well as the cancer-associated fibroblasts in pancreatic cancer (229)

The study supports the role of GPX in redox balancing under multi-stress conditions and highlights candidate genes for resistance breeding