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3 Am J Physiol Regul Integr Comp Physiol Characterization of pituitary IGF-I receptors (Fruchtman et al., 2002)Demonstrates des(1-3)IGF-I binds the IGF-I receptor with high affinity but IGF-binding proteins weakly, and is more potent than IGF-I in a receptor-mediated readout &mdash

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Interestingly, iron deficiency also aggravated RM-induced AKI by enhancing catalytic heme-iron-modulated lipid peroxidation and DNA oxidation, upregulating the activity of p53/p21 and promoting cellular senescence [162]

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