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Treatment can be administered in both knees simultaneously and at different times, depending on individual requirements

Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled trial

[15] If a scheduled injection is missed, the patient should administer the dose as soon as remembered unless it is within 24 hours of the next scheduled dose, in which case the missed dose is omitted to prevent overlap

The cycle is 30 days on, 30 days off

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