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Human metabolomics studies have shown that IPF lung tissues displayed increased glycolysis compared with healthy controls (Zhao et al., 2017)

It is established that many of these CYP450 genes are subject to genetic polymorphisms, resulting in an altered expression and function of individual enzymes

Studies in human embryonic kidney 293 (HEK 293) cells overexpressing hOAT3 showed that there was an enhanced uptake of MPAG (Uwai et al., 2007), morinidazole glucuronides (Zhong et al., 2014), daidzein-7-O-glucuronide, genistein-7-O-glucuronide, glycitein-7-O-glucuronide and quercetin-3-O-glucuronide (Wong et al., 2011), which suggested that OAT3 contributes to the renal tubular secretion of these glucuronide conjugates

doi: 10.1016/S0009-9120(01)00271-5