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Br J Pharmacol 1970;39: 653655.CrossRefGoogle Scholar Well-Malherbe

doi: 10.3389/fimmu.2013.00141

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Drugs with a high first-pass metabolism, such as morphine, propranolol and verapamil, have a low oral bioavailability and oral doses are, consequently, much higher than intravenous doses

Harnessing the therapeutic potential of hepatokines and addressing metabolic dysfunction may not only decelerate AD progression but also transform paradigms in neurodegenerative disease management