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The higher the score on the questionnaire, the more likely the patient needs aggressive treatment

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Mediation analysis for secondary outcome 7 will be performed by partitioning total effects into direct and indirect effects, 19 and secondary outcomes 816 will be analysed using a likelihood-based linear mixed effects model for repeated measures with covariate adjustment for baseline scores and prognostic factors used for group allocation

doi: 10.1016/j.imbio.2012.07.031 101 WagnerCHnschGMStegmaierSDeneflehBHugFSchoelsM