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When synaptic depolarization occurs (typically through AMPAR activation), the driving force for Mg 2+ entry is reduced and the ion is expelled from the pore, thereby relieving the block and allowing current to flow (Nowak et al., 1984

While autophagy suppresses apoptosis and pyroptosis by degrading Caspase-8 [162], excessive autophagy (autophagic cell death) releases unprocessed autophagosomes containing free fatty acids and ROS (O 2 - , H 2 O 2 ), activating RIPK1-dependent necroptosis [163]

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In addition to the dietary nutrients entering the gastrointestinal tract, other substances from endogenous sources, such as saliva, bile, urea, glutathione, etc., simultaneously enter into the lumen where they can be metabolized by the microbiota (59)