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The latter includes the upregulation of key antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-disulfide reductase (GSR), and downregulation of enzymes producing excess nitric oxide (NO) like the inducible nitric oxide synthase (iNOS/NOS2)

10.1042/BJ20101884 Biochem

However, this is insufficient to counteract erythrocytes vulnerability to oxidative stress in G6PD def
Interrogation of the NRF2 E79Q tumors revealed significantly higher PMN-MDSCs and a shift from M1 to M2 macrophages relative to the NRF2-wild-type tumors [54]

IGF-1R was the first tyrosine kinase targeted by a monoclonal neutralizing antibody (alpha-IR-3) that blocked the receptor binding domain (204)
