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In turn, these free radicals cause further mitochondrial damage and so create a vicious cycle of less energy and more damage

Targeting DNA repair pathway in cancer: Mechanisms and clinical application

Phenolics become active antioxidants when substitution at either the ortho- or para-position enhances the electron density at the hydroxyl group, which in turn reduces the oxygenhydrogen bond energy and increases reactivity against lipid free radicals
Figure EV6 Metabolic characterization of A549shNRF2-/H460shNRF2-BIND rescue cell models
This process is presumed to have led to the emergence of a number of complications, such as hot flashes (or vasomotor symptoms), chronic kidney disease (CKD), cardiovascular disease, and neurodegenerative disease ( The menopausal estrogen depletion-induced renal redox imbalance has been considered a primary factor that contributes to aging acceleration ( Hypericum perforatum L (HPL) has been used as an estrogenic botanical in the menopausal period to treat depression and anxiety, reduce vasomotor symptoms (e.g., hot flashes), modify reproductive-urinary system dysfunctions, rescue cognitive impairment, and balance lipid metabolism ( in vivo and in vitro , thereby ameliorating renal and podocyte injury to reduce albuminuria in individuals with early diabetic nephropathy ( Here, we investigated whether an HPL treatment might reduce disturbances in the kidney microenvironment associated with fluctuating protein and metabolite levels following ovarian exhaustion