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Tocopherol derivatives may be effective in the improvement of locomotor activity and motor coordination in haloperidol-induced PD [71]

sc) did not improve renal outcomes in patients with acute renal failure, compared to placebo, after a mean period of 10 days.36 To account for co-founding factors in acute renal injury, recombinant IGF-1 administration was also tested in transplant patients receiving a cadaveric kidney allograft.37 In these patients, treatment with IGF-1 similarly failed to significantly improve renal function compared to placebo, suggesting that the regenerative effects of IGF-1 observed in animal models of renal ischemia may not be directly scalable to patients with acute renal failure

Out of the top 20 gene sets enriched in each condition, 9 gene sets, including Heme metabolism and ROS pathway, were common to all 4 conditions and an additional 3 gene sets, including Cholesterol synthesis were enriched in 3 out of 4 conditions (Figure 3B, S3AB)