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Persistent inflammation triggers the activation of macrophages and microglial cells, thereby instigating the release of ROS and inducing oxidative stress (124)
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Some studies have suggested that activation of the Wnt/-catenin signaling pathway can induce apoptotic cell death, at least in part, through a caspase-dependent mechanism ( Vitamin C, a potent antioxidant, can alleviate various organ injuries by reducing oxidative stress
