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doi:10.1210/jc.2005-1536 Sikiric P, Seiwerth S, Rucman R, et al

They can improve the stemness, persistence, metabolic adaptability and anti-tumor activity of CAR-T cells, and help to improve the therapeutic effect

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Consequently, there are problems for their use as therapies that are related to variability of strains, variability of hosts, and the need to standardize procedures