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Two further phase II trials (280, 281) with larazotide acetate failed in finding an improvement in intestinal permeability, whereas the last trial published (282) underlined possible usefulness in refractory CD, defined as malabsorption and continued villous atrophy on duodenal biopsies despite strict avoidance of gluten for a minimum of 12 months (283)

Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans

Additionally, specific Vitamin B12 deficiency tests, such as ethylmalonic acid level (MMA) or Schilling test, are used to identify the deficiency

Acknowledgments The authors thank Dr

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