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Central to this approach are dose modification protocols guided by the Common Terminology Criteria for Adverse Events (CTCAE), which provide standardized thresholds for adjusting or withholding treatment based on toxicity grade

Fundam Appl Toxicol 1993;20:97110

doi: 10.1038/s41420-024-01991-8 65 KimRHashimotoAMarkosyanNTyurinVATyurinaYYKarGet al

When these excess ketones get into the blood, the blood becomes acidic, causing DKA, which is a combination of very high blood sugar, dehydration and shock, and exhaustion