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In contrast, SBS-PolkKO mutations have no replication strand asymmetry (Fig
The Randle cycle essentially describes that when fatty acid oxidation is active there is a significant reduction in the uptake and utilization of glucose by inhibition of PDH flux, but it also works the other way around, so the production of acetyl-CoA from glycolysis will inhibit fatty acid oxidation through the generation of malonyl-CoA which can inhibit CPT I [99]
Nature 438, 662666
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Adding semaglutide to this situation creates a double hit on absorption capacity
