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Thus, fungal dysbiosis, characterized by a decrease in fungal diversity and an increase in certain opportunistic pathogens, such as Candida albicans and Malassezia [143], has been reported in diseases such as IBD [144], colorectal cancer [145], and sepsis [146]

Participants may expect as many as 20 visits over the 75-week trial, but aside from the baseline and 64-week health checks, its unclear what will happen at each visit

doi: 10.1056/NEJM197111182852108

Consequently, the authors suggest that the peptide may engage a caspase-3/7-dependent route downstream of mitochondrial stress