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Oxidative stress occurs when the balance between pro-oxidants and antioxidants in the body is disrupted, leading to an overproduction of ROS, causing damage to cellular components
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Free Radical Biol Med 135:4659 Francis S, Kramarenko I, Brandon C, Lee F, Baker T, Cunningham L (2011) Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32
