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The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

10.1371/journal.pone.0039888 132 MllerW.HuingerK.Ziegler-HeitbrockL.HeyderJ

This lifelong therapy rapidly corrects deficiency, restores red blood cell production, and protects nerve function

First-Line Treatments: Where OTC Antiperspirants Fall Short Clinical guidelines from the American Academy of Family Physicians (AAFP) and the International Hyperhidrosis Society recommend topical aluminum chloride hexahydrate (1520%) as a first-line option