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The result with plasma gel is usually subtler and more progressive

Effects of SGLT2 inhibitors on cardiovascular outcomes in patients with stage 3/4 CKD: a meta-analysis

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Simultaneously, they experience active efflux involving multidrug resistance proteins (MRP) and PgP, through which the majority of absorbed molecules are pumped back into the extracellular or intestinal space, further reducing their bioavailability [19]

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