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It acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase, enzymes that are critical for one-carbon metabolism as well as the catabolism of odd-chain fatty acids and branched-chain amino acids (Rucker et al., 2007)

neither the European Union nor the granting authority can be held responsible for them

Remarkably, overexpression of HSL alone, in the absence of the M2-polarizing cytokine (IL-4), was sufficient to induce a pro-resolving phenotype in nave macrophages

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however, if not administered at the same time, they should be administered sufficiently close in time so as to provide the desired therapeutic or prophylactic effect