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Although it remains challenging to obtain direct evidence, since most available tools, techniques, and model systems lack the resolution to clearly establish causality, many neurodegenerative diseases are strongly associated with energy failure, which ultimately contributes to neuronal death (discussed in more detail later)

[DOI] [PMC free article] [PubMed] [Google Scholar] 68.zenolu A., Anul N., zeliki B

If you take a B-complex, taking it at the same time as ALA is perfectly fine and may help offset any potential biotin competition at higher doses

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Psychiatry 31 CockshellS