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Description
Interestingly, flavanones are responsible for the characteristic bitter taste found in the juice and peel of citrus fruits

Nuclei were resuspended in 0.2 M H 2 SO 4 (added at 1:5 vol/vol) and incubated at 4C for 4 h with constant rotation

The isolation procedure was performed at 4 C

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563 Monitoring and considerations include dose titration, initiating medications at low doses and gradually increasing to the maximum tolerated dose while monitoring efficacy and adverse effects