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doi: 10.3390/antiox11040660 175 KotterM

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It is therefore likely that ADA2 deficiency causes increased cell death via an indirect route that is not immediately fixed by adding functional ADA2

Graphical abstract Access this article Similar content being viewed by others Abbreviations ACh: Acetylcholine AChE: Acetylcholinesterase AD: Alzheimers disease ApoE: Apolipoprotein E APP: Amyloid precursor protein A: -Amyloid A42: Amyloid-42 BBB: Blood-brain barrier BMP9: Bone morphogenetic protein 9 CFC: Chlorofluorocarbons CNS: Central nervous system CSF: Cerebrospinal fluid DNA: Deoxyribonucleic acid DTE: Drug targeting efficiency DTP: Drug transport percentage EMA: European Medicines Agency FDA: Food and Drug Administration FID: Fluorescein isothiocyanate dextran HFA: Hydrofluoroalkane NSAID: Non-steroidal anti-inflammatory drug PACAP: Pituitary adenylate cyclase activating polypeptide PET: Positron emission tomography PLGA: Poly(lactide-co-glycolide) acid PLA: Polylactide SLN: Solid lipid nanoparticles TFB: Tarenflurbil TMME: Tacrine mucoadhesive/microemulsion References Chen WW, Zhang X, Huang WJ