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Probiotics play a central role, with Lactobacillus rhamnosus, Lactobacillus reuteri, Bifidobacterium longum, and Bifidobacterium bifidum strains being particularly effective in improving gut health, reducing systemic inflammation, and positively influencing testosterone levels and sperm quality, as reported by Raheem et al [229]

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Studies show that RNAi-induced GPX4 downregulation is sufficient to induce ferroptosis, while GPX4 overexpression in HT-1080 cells confers resistance to ferroptosis, and GPX4-deficient cells are more susceptible (Yang et al., 2014)