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Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S, et al

Moreover, the anti-apoptotic effect of sitagliptin manifested by lessening expression of Bax and caspase 3 enzyme further contributed to protection against cyclophosphamide-induced cerebral neuronal damage

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It is supposed that antidepressants such as tricyclic antidepressants or the serotonin norepinephrine reuptake inhibitors may be involved in the reinforcement of the descending inhibitory pathways by increasing the amount of norepinephrine and serotonin in the synaptic cleft at both supra-spinal and spinal levels [11]