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In pernicious anemia, holotranscobalamin decreases whereas in dietary deficiency, holotranscobalamin will remain relatively stable while total serum B12 decreases

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It should only be administered under strict medical supervisionideally through an institutional review boardapproved trial

Methylmalonic Acid Homocysteine Notes on Clinical Trials of B12 Supplementation Although not addressed in the graphs, younger people who start out deficient tend to have more drastic, initial drops in MMA and homocysteine
