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From these findings, it appears clear that BDNF is implicated in the mechanism of action of drugs that improve cognitive deficits in animal models of AD and AD patients

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The subunit is encoded by the IDH3G gene which is located on chromosome Xq28 and is composed of 12 exons that generate two alternatively spliced mRNAs encoding precursor proteins of 393 amino acids (isoform a) and 380 amino acids (isoform b)