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The inhibition of miR-155 rescues redox homeostasis and mitochondrial dynamics in diabetic tissues via AMPK-PGC1 signaling (Prieto et al., 2023

1,2 The number of patients with diabetes globally is expected to reach 783 million by 2045

While directly taking oral glutathione supplements is notoriously ineffective because the fragile molecule is poorly absorbed and rapidly broken down by digestive enzymes in the gastrointestinal tract, NAC successfully bypasses these physiological hurdles

This phenomenon could be further exacerbated by the depletion of the methyl donor S-adenosylmethionine (SAM) pool, as a consequence of VitB12 deficiency, a universal methyl donor needed for the methylation of DNA, RNA, proteins, neurotransmitters, and phospholipids
