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Description

Topical application of green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) resulted in the inhibition of prostaglandin metabolites, including prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), and prostaglandin F2 (PGF2) [49]

The constrained bioavailability of orally administered EGCG arises from factors including extreme pH conditions, digestive enzymes, and EGCGs restricted membrane permeability within the intestinal wall (9)

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A pilot study found that NAC induced a faster normalization of lactate levels [an predictor of severity and death (White et al., 1985)] in patients with severe malaria compared to the placebo (Watt et al., 2002), supporting its potential use as an adjunctive treatment for severe malaria patients