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Additionally, many genes associated with mitochondrial integrity, including stability, fusion, and mitophagy, were increased in bones of Dmp1-Cre

MOTS-c works at the cellular metabolic level (AMPK pathway, mitochondrial signaling)

, Sabbatini R., Garofalo C., et al

Thus, the relevant consequence is the high extent of the loss of the muscle strength MFI as the notation of the muscle failure, and thereby high MFI

However, this adaptive mechanism may not be sufficient to counteract the overwhelming oxidative burden caused by iron overload ( Moreover, the use of antioxidants has been explored as a potential therapeutic strategy to mitigate oxidative stress in thalassemia patients