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The difference between the two treatments is how they achieve this

Two main pathways can trigger this process, the intrinsic, also called mitochondrial pathway, when apoptosis is initiated by the internal signals of mitochondrial origin, and the extrinsic when apoptosis is activated by external stimuli [16]

Glutathione can increase fat burning, especially in older patients, thus improving insulin resistance

Hence, probing for GSH-synthesising enzymes may help, in a recurrent setting, to predict the response to combinatorial therapies of erlotinib and GSH level increasing agents

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