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Dermoscopically, gray homogeneous bands suggest activation, while brown or black bands suggest proliferation.2 The third step is to determine whether the melanocytic proliferation corresponds to a benign condition (acquired, congenital, or lentiginous nevi) or a malignant one (subungual melanoma)

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Future treatment strategies should integrate genotype-specific resistance profiling with immune-modulating approaches to limit RAS selection and improve patient outcomes